Our Comfort Inn® hotel in Poplar Bluff is located in southeastern Missouri and is known as the Gateway to the Ozarks. This small town is located in the middle of three large cities, making it a popular getaway town for those escaping the city. Once you get here, the tranquil atmosphere will surround you and you can slow down your pace. Simply get outside, enjoy the sights and sounds of nature. You might even consider a hike or walk on the trails near the Ozark Mountains.